Abstract: At least 25% of Crohn’s disease (CD) were onset during the childhood, and reach its peak at growth spurt puberty which also is the critical periods of emotional and physical development. Almost all children with CD have growth retardation, malnutrition, micronutrients deficiency, even overweight or obesity at diagnosis and during subsequent courses of disease. The latest inflammatory bowel disease (IBD) nutrition guideline indicated that all patients should be screened for risk of malnutrition at admission and periodically followed-up using a validated screening tool. ECCO/ESPGHAN latest guideline announced that exclusive enteral nutrition (EEN) should be used as the first-line treatment in pediatric patients with CD. Studies had confirmed that EEN was superior to hormone in inducing mucosal healing, restoring bone density, and promoting growth and development without hormone related adverse reactions. This article reviews the progress in application of EEN in pediatric patients with CD.